As a step towards creating an evidence-based fundament for Transformational Psychotherapy, ​RECONNECT Foundation is currently supporting a multi-year clinical research programme at the University Hospital of Psychiatry in Zurich. The goal is to understand the neurodynamic mechanisms of stress-related and affective mood disorders, and to investigate how psychointegrative plant medicine can be used for neurodynamic resetting as a precursor for efficient psychotherapeutic learning and correcting pathological psychological processes and behavioural patterns.

​Mechanistic understanding of Dimethyltryptamine and MAO-I using multimodal imaging

​Within this project, ​the plan is to prepare a standardized and quality-controlled botanical extract for orally activated DMT to test the neuroscientific research hypothesis, using multimodal neuroimaging technology in healthy subjects, that pharmacological modulation of glutamate- and serotonin-responsive cerebral circuits uniquely predicts behavioral change in terms of enhanced adaptive neuroplasticity, emotion regulation, cognitive flexibility, and mindfulness-related capabilities. Providing a solid neuroscientific basis of serotonergic and glutamatergic modulation, we pave the way for future development ...

​Clinical efficacy study in patients with affective mood disorders

​While ketamine and psilocybin have been researched extensively in the past 20 years, scientific interest in ayahuasca / DMT just started to raise due to its potential therapeutic benefits (​Frecska, 2016; ​​Labate, 2013). Ayahuasca was used in the Amazon as traditional indigenous medicine but is currently spreading all over the world as an alternative plant medicine with increasing numbers of Westerners seeking treatment in established retreat centers in South America (​​​Tupper, 2008). This rapid dissemination points to 1) an unmet need for increased psychosocial well-being through rapid and sustainable relief from various mental health problems and 2) to the observational evidence that ayahuasca provides a pharmacological tool to facilitate transformational processes with beneficial health outcomes. However, solid empirical research is needed to move beyond anecdotal evidence and further verify therapeutic efficacy and biomechanisms of ayahuasca / DMT under controlled laboratory settings.

Related ​peer-review publications



​Affective mood disorders

​Neuronal underpinnings